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3 per 1,000 PY for CAC 1,000; by number of vessels with obstructive disease 6.1 per 1,000 PY for no CAD to 34.7 per 1,000 PY for 3-vessel disease). When stratified by 5 groups of CAC scores (0, 1 to 99, 100 to 399, 400 to 1,000, and 1,00, the presence of obstructive CAD was not associated with higher risk than presence of nonobstructive CAD. Plaque burden, not stenosis per se, is the main predictor of risk for CVD events and death. Thus, patients with a comparable calcified atherosclerosis burden generally carry a similar ri