https://www.selleckchem.com/pr....oducts/17-AAG(Geldan
Recent research has begun to explain this paradox by demonstrating cell type-specific and physiological/pathological context-dependent roles for IGFBP-5. In this review, we survey and discuss what is currently known about IGFBP-5 in normal physiology and human disease. Based on recent in vivo genetic evidence, we suggest that IGFBP-5 is a multifunctional protein with the ability to act as a molecular switch to conditionally regulate IGF signaling. Copyright © 2020 Duan and Allard.Osteoporosis is a significant cause of morbi