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Copyright © 2020 Li, Pan, Nguyen, Ren, Moodley and Sangild.Systemic lupus erythematosus (SLE) is described as high quantities of autoantibodies and multiorgan injury. The pathogenesis of splenomegaly in SLE remains unidentified. In this research, the role of immunoglobulin G (IgG) generation and deposition within the infection regarding the spleen and connected disorder in SLE was examined. In the lupus mice, we observed the development of spontaneous spl