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In this manuscript, we review the continuous efforts dealing with this unmet medical need including the continuous improvement non-covalent BTK inhibitors, BTK degraders, novel BH3-mimetics, therapeutic antibodies targeting novel antigens and resistant cell allowing treatments. Patients undergoing ViV-TAVI for degenerated bioprostheses were prospectively most notable study. The risk of coronary obstruction among customers addressed with stented va
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