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For both groups, overall tumor response was more than 80%, with a similar incidence of BNCT-induced severe mucositis. CONCLUSION(S) The twice-interrupted protocol reduced severe mucositis during cancerization without affecting tumor development. This favoured the animal's welfare and reduced the number of animals to be cancerized for our studies, without affecting BNCT response. This article is protected by copyright. All rights reserved.This study aimed to investigate the effect of resveratrol on methane production, rumen fermentation