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The evidence for adults with physical or mental ill health is more positive although limited by small samples and variability in nutrients studied. Broad spectrum nutrient products may be more effective than a selected few. While an effect of micronutrients cannot be dismissed, the variability of the studies makes it extremely challenging to identify specific treatment benefits.Introduction Junctional epidermolysis bullosa (JE is a rare inherited genetic disorder with limited treatments beyond palliative care. A major hallmark of JEB