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An even more sensitive and painful assay will become necessary. IFN-γ-induced protein 10 (IP-1 is an alternate biomarker with a 100-fold-higher expression level than IFN-γ, permitting different evaluation systems, including molecular recognition. The PCR technique is already an integral tool in most TB laboratories and, therefore, an obvious platform to turn to. In this case-control study, we investigated the diagnostic sensitiveness and specificity of a molecular assay detectin