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Dysregulated PTMs may influence the propensity for protein aggregation in NDD-proteinopathies. To investigate this, we systematically evaluated the literature to evaluate results of PTMs on aggregation tendency for significant proteins for this pathogenesis and/or development of NDDs. A search of PubMed, MEDLINE, EMBASE, and Web of Science Core Collection had been carried out to access researches that investigated an association between PTMs and protein aggregation in seven NDDs Alzheimer'