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ADHD and Sleep Medication People with ADHD struggle to sleep. They are restless when they finally do get to sleep, and they are awake frequently throughout the night. and polysomnography, which are both objective measures which show that children suffering from ADHD sleep later and have a lower sleep efficiency than their control counterparts. However, objective measures of sleep improve with methylphenidate (MPH) treatment. 1. Restlessness medication to calm nerves AD