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The EEG power spectral density (PSD) analysis revealed an increased PSD of pre-ictal delta in Sham-M animals and increased PSD of slow, center and fast gamma oscillations after memantine injection that persists through the pre-ictal period in most groups. Our findings suggested that memantine was unable to control the PTZ-induced seizures and therefore the connected enhancement of PSD of gamma oscillations may subscribe to the increased possibility of seizure devel