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Exploring the factors that determine nerve size in childhood CMT1A may lead to the development of treatments.Concurring with the authors of Rehm et al., this comment endorses their recommendations, but points out that adult household population surveys will still be valuable in cross-sectional and panel series long based on this frame, recognising too that to fully account for heavy drinkers beyond this frame, though valuable, is onerous (by providing one rigorous example from a county study). Last, the importance of attending to impro