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Chlorhexidine and povidone-iodine are the most common disinfectants used in preoperative skin preparation. However, there is no consistent conclusion regarding the prevention of surgical site infection (SSI) and bacterial culture data. To assess the efficacy of chlorhexidine and povidone-iodine in the prevention of postoperative SSI and relevant bacterial data. Systematic Review and Meta-Analysis SETTINGS N/A PARTICIPANTS N/A METHOD Literature relevant to "skin antisepsis" and "surgical site infections" was retrieved from PUBMED, Web of S