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The color development was stopped and the intensity of the color was measured. The liver regeneration rate (%) was significantly higher in the group of rats treated with IL-6 (median value was 49.55% vs. 33.20%), 0.001. The MMPs' serum level was significantly higher in the group of rats with resection and treatment (median value was 8.01). These results give evidence for the vital role of MMPs in the process of hepatic regeneration, the level of which, in turn, has a close relationship with the level of IL-6. MMPs have diverse effe