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ADHD Treatment Medication Treatment for ADHD for adults usually involves psychosocial therapy and medication. The medications used to treat ADHD include stimulants and nonstimulant medication. Stimulants such as methylphenidate or Lisdexamfetamine work on chemical messengers in the brain to boost mood, concentration, and impulse control. Atomoxetine and guanfacine are nonstimulant ADHD medicines that may be given to teenagers, adults or children if they do not respo