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The participation of oxidative tension into the development of obesity continues to be unclear. Although primarily present in peroxisomes, catalase scavenges intracellular H2O2 at toxic amounts. Therefore, we used catalase-knockout (CKO) mice to elucidate the participation of excessive H2O2 when you look at the growth of obesity. CKO mice with C57BL/6J background gained more weight with greater body fat size with age than age-matched wild-type