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The influence of PRH on protein quantities of CYP3A4 as well as other crucial CYP enzymes, and also the k-calorie burning of nifedipine (a CYP3A4 substrate generally prescribed during pregnancy), ended up being evaluated in primary person hepatocytes. Sandwich-cultured human hepatocytes (SCHH) from female donors had been confronted with PRH (estradiol, estriol, estetrol, progesterone, and cortisol), separately or perhaps in combo as a cocktail. Absolute ne