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Diabetes mellitus is a serious global health issue, currently affecting 425 million people and set to affect over 690 million people by 2045. It is a chronic disease characterized by hyperglycemia due to relative or absolute insulin hormone deficiency. Dipeptidyl peptidase-IV (DPP-IV) inhibitors are hypoglycemic agents augmenting the action of the incretin hormones that stimulate insulin secretion from the pancreatic beta cells. In this study synthesis and biological evaluation of seven piperazine derivatives 3a-g was carried out. The sy
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