https://www.selleckchem.com/pr....oducts/Streptozotoci
Sacubitril/valsartan (sac/val) has shown superior effect compared with blockade of the renin-angiotensin-aldosterone system in heart failure with reduced ejection fraction. We aimed to investigate effects of sac/val compared with valsartan in a pressure overload model of heart failure with preserved ejection fraction (HFpEF). Sprague-Dawley rats underwent aortic banding or sham (n=16) surgery and were randomized to sac/val (n=28), valsartan (n=29), or vehicle (n=26) treatment for 8weeks. Sac/val reduced left ventricular weight by
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