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Medication For ADHD - What Are the Side Effects? Many people suffering from ADHD experience improvements in their symptoms with medication. However, each person reacts differently to different medications, and adverse reactions can be problematic. Methylphenidate is a stimulant. It works by raising levels of a chemical within the brain that assists in controlling the behavior and attention. Stimulant drugs Stimulant medications improve concentration and attention for 70% to 80% children a