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This review aims to cover the utilizes regarding the commercially offered protease Alcalase into the production of biologically active peptides since 2010. Immobilization of Alcalase has additionally been assessed, as immobilization of the chemical may improve final response design allowing the utilization of even more drastic circumstances and also the reuse of the biocatalyst. This way, this review presents the manufacturing, via Alcalase hydrolysis of diffe