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merozoite and gamete stages compared to sporozoites. Recent breakthroughs in host-pathogen interaction and host restriction have significantly expanded the understating of the unique biology of these pathogens. This review aims to critically explore advances in the sexual cycle of Coccidia parasites with the ultimate goal of comparing and analyzing the sexual cycle of Eimeria spp. and T. gondii.Trypanosoma cruzi, Trypanosoma brucei and Leishmania (Trypanosomatidae Kinetoplastida) are parasitic protozoan causing Chagas disease, African