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oposed DNN-based WB internal dosimetry exhibited comparable performance to the direct Monte Carlo approach while overcoming the limitations of conventional dosimetry techniques in nuclear medicine. The proposed DNN-based WB internal dosimetry exhibited comparable performance to the direct Monte Carlo approach while overcoming the limitations of conventional dosimetry techniques in nuclear medicine.Vismodegib displays unique pharmacokinetic characteristics including saturable plasma protein binding to alpha-1 acid glycoprotein (AAG) and