https://www.selleckchem.com/pr....oducts/gsk650394.htm
Among the members of the tumor necrosis factor receptor superfamily, there are 4-1BB and OX40. Several clinical studies have been carried out targeting these molecules, with agonist monoclonal antibodies, and preclinical studies exploring their ligands and other experimental approaches. In this review, we discuss functional aspects of 4-1BB and OX40 costimulation, as well as the progress of its application in immunotherapies.Reactive oxygen species (ROS) oxidize surrounding molecules and thus impair their functions. Since mitochondria
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