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BACKGROUND Postpartum developmental delay has been proposed as an important phenotype of human evolution which contributes to many human-specific features including the increase in brain size and the advanced human-specific cognitive traits. However, the biological processes and molecular functions underlying early brain development still remain poorly understood, especially in human and primates. RESULTS In this paper, we comparatively and extensively studied dorsolarteral prefrontal cortex expression data in human and chimpanzee to in