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Pyroptosis is a lytic, pro-inflammatory cell death program that is tightly regulated by inflammasomes in most cases. Inflammasome-dependent pyroptosis is best characterized in myeloid cells, but there is growing evidence that this cell death program also functions in human T cells. Several studies have suggested a role for inflammasome components in T-cell biology but often do not unambiguously clarify whether this means that T cells progress to pyroptosis. Pyroptosis has distinct morphological features, such as early loss of membrane in