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A "Bowman's like layer" can generate around stromal epithelial plugs after radial keratotomy, and possibly beneath the central corneal epithelial basement membrane many years after PRK. The main aims of this study were (1) to investigate whether a blockade of the interaction between the receptor activator of nuclear factor-κB (NF-ĸ ligand (RANKL) and its receptor RANK may have potential as a novel therapeutic strategy for allergic asthma; (2) to compare the efficacies of the blockade of RANKL/RANK interaction as well as the blockade