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These details may assist in clinical decision-making for pharmacological interventions designed to address fragility in OI. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. with respect to American Society for Bone and Mineral Research.Estrogen deficiency and aging play crucial functions into the pathophysiology of bone tissue due to increased oxidative stress. It's been recommended that avoidance of NADPH oxidase- (Nox-) centered accumulation of ROS could be