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How Does Medication For ADHD Work? The most commonly prescribed medications doctors prescribe to treat ADHD work by increasing levels of chemicals in the brain called dopamine and norepinephrine. They are available in short-acting versions and extended-release. It may take some time before you or your child discover the right dosage and medication for them. Lifestyle changes can improve symptoms, in addition to medications. Methylphenidate Methylphenidate is a central nerve stimul