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In the shuttle box, both RVG and ∆RVG decreased the time spent in the dark compartment compared to control (p less then 0.05). In MWM, RVG and ∆RVG did not affect the acquisition of spatial task. In the probe test, RVG-expressing rats spent more time in the target quadrant, and also reached the platform position sooner than control group (p less then 0.05). Rats expressing ∆RVG significantly swam farther from the hidden platform than RVG group (p less then 0.05). Our data indicate RVG expression in the hippocampus strengthens aversive an
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