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The aim of the study was to assess human norovirus and feline calicivirus (FCV) surface free energy, hydrophobicity, and ability to interact with fresh foods and food-contact surfaces. Virus-like particles (VLPs) of human norovirus (GI.1 and GII.4) and FCV were produced, purified, and analyzed for their surface free energy, hydrophobicity, and the total interfacial free energy of interaction [Formula see text] with lettuce, strawberry, polyethylene, and stainless steel. GII.4 VLPs were further tested for adhesion at different pH, ionic st