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Finding the Best ADHD Medication For Adults The use of medications is the foundation of many adult ADHD treatment plans. Finding the right dosage and medication is not always easy. Stimulants: These drugs are used to treat hyperactivity and inattention. They work by increasing levels of chemicals in the brain that transmit messages between nerve cells. They are typically taken multiple times per day and start working in less than an hour. Stimulants Stimulants are the first medicati