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Finally, the tumor microenvironment may have an evolving role in the future. GC is a heterogeneous disease and targeted approaches are needed. The finding of prognostic and predictive factors is a hot topic in the field of GC personalized medicine. GC is a heterogeneous disease and targeted approaches are needed. The finding of prognostic and predictive factors is a hot topic in the field of GC personalized medicine. Clinical trials have proven a survival benefit from applying local therapies for oligometastatic cancers of various orig