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Both Major depressive disorder (MDD) and insomnia are two common mental disorders. However, the inherent and comprehensive genetic factors causing the links between MDD and insomnia are unclear yet. Here, based on GWAS results for each disorder, we used linkage disequilibrium (LD) score regression analysis and a multi-single nucleotide polymorphism (SNP) Mendelian randomization (MR) analysis to test the genetic relationships between these two diseases. Genetic correlation analyses indicated that MDD has a significant gen