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012). No significant differences were apparent in disease-related biomarkers between the groups. M. officinalis extract containing 500 mg of RA taken daily was safe and well-tolerated by patients with mild dementia due to AD. Our results suggest that RA may help prevent the worsening of AD-related neuropsychiatric symptoms.Trial registration The registration number for this clinical trial is UMIN000007734 (16/04/2012).This study highlights the severity of the low snow water equivalent (SWE) and remarkably high temperatures in 2020 in Ja