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The development of effective medications and vaccines against Vibrio parahaemolyticus is the existing research priority. Therefore, we aimed to learn effective drug and vaccine goals utilizing an extensive genome-based analysis. A total of 4822 proteins had been screened from V. parahaemolyticus proteome. Among 16 novel cytoplasmic proteins, 'VIBPA Type II secretion system necessary protein L' and 'VIBPA Putative fimbrial protein Z' had been afflicted by molecular docking with 350 real