https://gsk343inhibitor.com/pl....uripotent-originate-
These three different web sites, Ser238, Thr245, and Ser262 were tested either by blocking their phosphorylation, by Ser/Thr to Ala replacement, or pseudophosphorylation, by changing Ser/Thr to Glu. We validate the hypothesis that phosphorylation at Ser262 is necessary for Tau-dependent understanding deficits and a "facilitatory gatekeeper" to Ser238 occupation, that is linked to Tau poisoning. Notably we reveal that phosphorylation at Thr245 acts as a "suppressive gatekee
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