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oxemia, lactacidemia, and hypocapnia. Because pulmonary hemodynamics and dyspnea at end-exercise remained unaltered, the hypoxia-induced exercise limitation may be due to a reduced oxygen delivery causing peripheral tissue hypoxia, augmented lactic acid loading and hyperventilation. ClinicalTrials.gov; No. NCT03592927; URL www.clinicaltrials.gov. ClinicalTrials.gov; No. NCT03592927; URL www.clinicaltrials.gov.Myst family genes encode lysine acetyltransferases that mainly mediate histone acetylation to control transcription, DNA re