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Usage of methamphetamine was significantly greater among SMM in Wave II who by design were older than Wave I. We have identified differences in methamphetamine use by race/ethnicity. Weekend use and poly-drug use were common among methamphetamine-using SMM. Data indicate differential use in the population and that attempts to address this addictive behavior must be linked to other drug use and socialization among young SMM. We have identified differences in methamphetamine use by race/ethnicity. Weekend use and poly-drug use were common