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The chosen examples include an individual non-ribosomal peptide synthetase SfmC that catalyzes crucial Pictet-Spengler reactions, which construct a characteristic tetrahydroisoquinoline skeleton in antitumor antibiotics such as saframycin, prenylation-oxidative customization enzymes involved in the biosynthesis of fungal tremorgenic mycotoxins such as for example penitrem along with functional Diels-Alderases