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Performance of these models was assessed using V1 and V2, both overall and in population-specific cohorts. RESULTS An AA-specific, automated stromal signature, AAstro, was prognostic of recurrence risk in both independent validation datasets [V1,AA AUC = 0.87, HR = 4.71 (95% confidence interval (CI), 1.65-13.4), P = 0.003; V2,AA AUC = 0.77, HR = 5.7 (95% CI, 1.48-21.9, P = 0.01]. AAstro outperformed clinical standard Kattan and CAPRA-S nomograms, and the underlying stromal descriptors were strongly associated with IHC measurements of sp
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