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Moreover, the bond strength ended up being more examined by carrying out a burst test for PDMS-PMMA, PDMS-PS, PDMS-PC, and PDMS-PET microfluidic devices, which were found to have the optimum force values at about 344.73, 448.15, 413.68, and 379.21 kPa, respectively. Predicated on these outcomes, the hybrid microfluidic products can be used for high-pressure experiments such as blood plasma separation and continuous-flow polymerase string response (CF-PCR).