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ailure and reduced LVEF. This included patients in sinus rhythm with suboptimal efficacy, as well as a cluster of patients with atrial fibrillation where β blockers did reduce mortality. Medical Research Council, UK, and EU/EFPIA Innovative Medicines Initiative BigData@Heart. Medical Research Council, UK, and EU/EFPIA Innovative Medicines Initiative [email protected] A (MCM-A) is a marine natural product belonging to a family of polyazole cyclopeptides with remarkable bioactivities and unique structures. Identification, hete