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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If a person is suffering from both ADHD and anxiety or depression, addressing the first can usually improve the second. prescribe antidepressants and stimulants for depression or antidepressants along with ADHD medication. Wellbutrin (bupropion) and Effexor, (venlafaxine), are two of the most popular antidepressants prescribed for ADHD "off-label". These medications increas