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Faecal microbiota transplant (FMT) is a highly effective therapy for recurrent infection (rCDI) with cure rates ranging between 85 and 92%. The FMT role for primary infection (CDI) has yet to be settled because of limited data and small-sample studies presented in the current literature. Our study goals were to report the risk factors and the risk of recurrence after FMT for each CDI episode (first, second, and third) and to explore if there is a role of FMT in primary severe CDI. We conducted a retrospective study to analyze the clinical