https://www.selleckchem.com/pr....oducts/pf-06952229.h
These findings contradict previous reports of the antinociceptive properties of the P. nitida alkaloids and the traditional use of akuamma seeds as analgesics. Nevertheless, their opioid-preferring activity does suggest the akuamma alkaloids provide distinct scaffolds from which novel opioids with unique pharmacologic properties and therapeutic utility can be developed.Clearance of peripheral amyloid-β (Aβ) has been demonstrated to be promising for overcoming the blood-brain barrier (BB hurdle to eliminate brain-derived Aβ associa
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