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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person suffers from both ADHD and depression or anxiety, treating the first can usually help the second. Mental health professionals typically prescribe antidepressants or a stimulant for depression along with an ADHD medication. Wellbutrin (bupropion), and Effexor, (venlafaxine), are the two most commonly used antidepressants prescribed for ADHD "off-label". These drugs increa