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To describe an immunocompetent patient with corneal endotheliitis caused by concomitant infection of cytomegalovirus and varicella zoster virus (VZV). A 37-year-old immunocompetent woman was referred to our hospital because of persistent corneal endotheliitis in the left eye. Slit-lamp examination revealed mild conjunctival injection, localized stromal corneal edema with underlying pigmented keratic precipitates, and inferior superficial corneal neovascularization. Anterior chamber examination revealed grade 2+ inflammatory cells. Real-tim