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Finally, an AhR antagonist improved voiding in AOAH-deficient mice. Together, these data demonstrate that AOAH regulates bladder function and that the AOAH-Crf axis is a therapeutic target for treating voiding dysfunction.Disruption of mitochondrial dynamics is an important pathogenic event in both acute and chronic kidney diseases, but the underlying mechanism remains poorly understood. Here we report the regulation of mitofusin-2 (Mfn2, a key mitochondrial fusion protein) by microRNA-214 (miR-214) in renal ischemia-reperfusion that con