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development of senolytic strategies to delay chronic ischemic renal injury.n/a. To identify novel disease associated loci for amyotrophic lateral sclerosis (ALS), we utilized sequencing data and performed and experiments to demonstrate pathogenicity of mutations identified in . We analyzed exome sequences of 87 sporadic ALS patients and 324 controls, with confirmatory sequencing in independent ALS cohorts of 2,800 patients. For the top hit, , a regulator of apoptosis, differentiation, and a binding partner as well as homolog of the t