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It is further replicated in the TwinsUK study with 1706 samples. The signal is driven by both low-frequency and common variants. [email protected]; [email protected]. Supplementary data are available at Bioinformatics online. Supplementary data are available at Bioinformatics online. Drug target interaction (DTI) prediction is a foundational task for in-silico drug discovery, which is costly and time-consuming due to the need of experimental search over large drug compound space. Recent years have witnessed promising progress for deep lea